PSMC6 Antibody

Code CSB-PA288074
Size US$297
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  • Western blot analysis of extracts from RAW264.7 cells, 293 cells and HepG2 cells, using PSMC6 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PSMC6 Polyclonal antibody
Uniprot No.
Target Names
PSMC6
Alternative Names
26S protease regulatory subunit 10B antibody; 26S protease regulatory subunit S10B antibody; 26S proteasome AAA-ATPase subunit RPT4 antibody; CADP44 antibody; P44 antibody; Proteasome 26S subunit ATPase 6 antibody; Proteasome subunit p42 antibody; PRS10_HUMAN antibody; PSMC6 antibody; Rpt4 antibody; SUG2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human PSMC6.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Gene References into Functions
  1. Evidence of a sex-specific association of PSMC6 genetic variants with subtypes of juvenile idiopathic arthritis. PMID: 24875235
  2. Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium. PMID: 25801217
  3. N protein of SARS Coronavirus interacts with the host cell proteasome subunit p42. PMID: 20478047
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
AAA ATPase family
Database Links

HGNC: 9553

OMIM: 602708

KEGG: hsa:5706

STRING: 9606.ENSP00000401802

UniGene: Hs.156171

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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