PSME4 Antibody

Datasheet
Code CSB-PA018919GA01HU
Product Type Purified Rabbit Anti Human,Mouse PolyClonal Antibody
Size US$685
Uniprot No. Q14997
Immunogen Human PSME4
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias proteasome (prosome, macropain) activator subunit 4;PSME4;FLJ21864;KIAA0077;MGC138374;MGC142228;PA200 ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names PSME4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
HGNC 20635
RGD 1591971
MGI 2143994
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Function Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis
Subcellular Location Cytoplasm, cytosol, Nucleus, Nucleus speckle
Protein Families BLM10 family
Database Links

HGNC: 20635

OMIM: 607705

KEGG: hsa:23198

STRING: 9606.ENSP00000384211

UniGene: Hs.413801

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