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PTCH2 Antibody, FITC conjugated

Datasheet
Code CSB-PA896928LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PTCH2 Polyclonal antibody
Uniprot No.
Q9Y6C5
Target Names
PTCH2
Alternative Names
patched (Drosophila) homolog 2 antibody; patched homolog 2 (Drosophila) antibody; Protein patched homolog 2 antibody; PTC2 antibody; PTC2_HUMAN antibody; Ptch2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein patched homolog 2 protein (793-951AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

PTCH2 Antibodies

PTCH2 Proteins

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Target Background

Function
Plays a role in the control of cellular growth. May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
Gene References into Functions
  1. Combined heterozygous germline mutations in PTCH1 and PTCH2 were identified in a patient with embryonal rhabdomyosarcoma. PMID: 29230040
  2. Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome. PMID: 23479190
  3. PTCH2 isoforms have distinct roles in Hedgehog signalling. PMID: 14613484
  4. PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS, resulting in the loss of PTCH2 inhibitory function in the Shh signalling pathway. PMID: 18285427
  5. A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported. PMID: 19208383

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Involvement in disease
Medulloblastoma (MDB); Basal cell carcinoma (BCC)
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Patched family
Database Links

HGNC: 9586

OMIM: 155255

KEGG: hsa:8643

STRING: 9606.ENSP00000361266

UniGene: Hs.591497

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Related pathways
Hedgehog signaling pathway
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