PTDSS1 Antibody

Datasheet

Code	CSB-PA04305A0Rb
Size	US$166
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Image	Western Blot Positive WB detected in: 293T whole cell lysate(20µg), K562 whole cell lysate(20µg), HepG2 whole cell lysate(20µg), MCF7 whole cell lysate(20µg All lanes: PTDSS1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/20000 dilution Predicted band size: 56,39,35 kDa Observed band size: 35 kDa Exposure time: 60s IHC image of CSB-PA04305A0Rb diluted at 1:150 and staining in paraffin-embedded humanpancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTDSS1 Polyclonal antibody

Uniprot No.

P48651

Target Names

PTDSS1

Alternative Names

PTDSS1 antibody; KIAA0024 antibody; PSSA antibody; Phosphatidylserine synthase 1 antibody; PSS-1 antibody; PtdSer synthase 1 antibody; EC 2.7.8.29 antibody; Serine-exchange enzyme I antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Phosphatidylserine synthase 1 protein (1-35AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PTDSS1 Antibody (Product code: CSB-PA04305A0Rb) is Non-conjugated. For PTDSS1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA04305B0Rb	PTDSS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA04305C0Rb	PTDSS1 Antibody, FITC conjugated
Biotin	CSB-PA04305D0Rb	PTDSS1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA,WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:3000
IHC	1:100-1:300

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.

Gene References into Functions

RYR2, PTDSS1 and AREG are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease. PMID: 26742492
PSS1 mutations not only affect cellular PS levels and distribution but also lead to a more complex imbalance in lipid homeostasis by disturbing PI4P metabolism. PMID: 27044099
Gain-of-function missense mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome. PMID: 24241535
Purification and characterization of human phosphatidylserine synthases 1 and 2. PMID: 19014349

Involvement in disease

Lenz-Majewski hyperostotic dwarfism (LMHD)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

Phosphatidyl serine synthase family

Database Links

HGNC: 9587

OMIM: 151050

KEGG: hsa:9791

STRING: 9606.ENSP00000430548

UniGene: Hs.292579

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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