Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTF1A Polyclonal antibody

Uniprot No.

Q7RTS3

Target Names

PTF1A

Alternative Names

bHLH transcription factor p48 antibody; bHLHa29 antibody; Class A basic helix-loop-helix protein 29 antibody; Class II bHLH protein PTF1A antibody; Exocrine pancreas specific transcription factor p48 antibody; p48 DNA binding subunit of transcription factor PTF1 antibody; p48 DNA-binding subunit of transcription factor PTF1 antibody; PACA antibody; PAGEN2 antibody; Pancreas specific transcription factor 1a antibody; Pancreas transcription factor 1 subunit alpha antibody; Pancreas-specific transcription factor 1a antibody; PTF 1A antibody; PTF1 p48 antibody; PTF1-p48 antibody; Ptf1a antibody; PTF1A_HUMAN antibody; PTF1P48 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.

Gene References into Functions

non-neural progenitor transcription factor Ptf1a alone is sufficient to directly reprogram mouse and human fibroblasts into self-renewable induced neural stem cells capable of differentiating into functional neurons, astrocytes and oligodendrocytes, and improving cognitive dysfunction of Alzheimer's disease mouse models when transplanted PMID: 30030434
Study describes the wide range of gene control by PTF1A that maintains the specific characteristics of pancreatic acinar cell identity and differentiation. PTF1A controls the pancreatic acinar transcription program by direct action at a thousand genes and in collaboration with other less cell type-restricted factors to ensure acinar cell homeostasis and to suppress other cell-type-specific programs. PMID: 27697859
Data show isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation PMID: 27284104
The results of this study suggested Ptf1a-dependent cell-fate misspecification as a novel mechanism of human brainstem pathology. PMID: 26937009
PTF1A enhancer mutations have been shown to cause neonatal diabetes associated with pancreatic agenesis PMID: 26184423
Loss of Ptf1a alone is sufficient to induce acinar-to-ductal metaplasia, potentiate inflammation, and induce a KRAS-permissive, pancreatic ductal adenocarcinoma-like gene expression profile. PMID: 26151762
The results of the present study do not support the hypothesis that high penetrant mutations in these regions of PTF1A are involved in the development of human VATER/VACTERL association or NTDs PMID: 25775927
ata indicate that E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a)and regulates PTF1a activities. PMID: 25355311
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. PMID: 24212882
ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression. PMID: 23339455
ptf1a functions as a "pancreatic determiner". PMID: 20668890
P48 interacts with the RBP-L and RBP-J subunits primarily through two short conserved tryptophan-containing motifs, similar to the motif of the Notch intracellular domain (NotchIC) that interacts with RBP-J. PMID: 16354684
Controls the fate, survival, differentiation, and migration of climbing fiber neurons during their development in the transgenic murine inferior olivary nucleus. PMID: 17928434
A critical and selective role of p/CAF in PTF1-dependent gene activation during acinar differentiation. PMID: 18834332
Here we report a new case of cerebellar agenesis and neonatal diabetes mellitus whose parents are PTF1A mutation carriers. PMID: 19650412
Two separable genomic regions code for initiation and positive feedback of Ptf1a transgene expression in the developing nervous system. PMID: 19741120