Recombinant Human Pancreas transcription factor 1 subunit alpha (PTF1A)

1. non-neural progenitor transcription factor Ptf1a alone is sufficient to directly reprogram mouse and human fibroblasts into self-renewable induced neural stem cells capable of differentiating into functional neurons, astrocytes and oligodendrocytes, and improving cognitive dysfunction of Alzheimer's disease mouse models when transplanted PMID: 30030434
2. Study describes the wide range of gene control by PTF1A that maintains the specific characteristics of pancreatic acinar cell identity and differentiation. PTF1A controls the pancreatic acinar transcription program by direct action at a thousand genes and in collaboration with other less cell type-restricted factors to ensure acinar cell homeostasis and to suppress other cell-type-specific programs. PMID: 27697859
3. Data show isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation PMID: 27284104
4. The results of this study suggested Ptf1a-dependent cell-fate misspecification as a novel mechanism of human brainstem pathology. PMID: 26937009
5. PTF1A enhancer mutations have been shown to cause neonatal diabetes associated with pancreatic agenesis PMID: 26184423
6. Loss of Ptf1a alone is sufficient to induce acinar-to-ductal metaplasia, potentiate inflammation, and induce a KRAS-permissive, pancreatic ductal adenocarcinoma-like gene expression profile. PMID: 26151762
7. The results of the present study do not support the hypothesis that high penetrant mutations in these regions of PTF1A are involved in the development of human VATER/VACTERL association or NTDs PMID: 25775927
8. ata indicate that E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a)and regulates PTF1a activities. PMID: 25355311
9. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. PMID: 24212882
10. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression. PMID: 23339455
11. ptf1a functions as a "pancreatic determiner". PMID: 20668890
12. P48 interacts with the RBP-L and RBP-J subunits primarily through two short conserved tryptophan-containing motifs, similar to the motif of the Notch intracellular domain (NotchIC) that interacts with RBP-J. PMID: 16354684
13. Controls the fate, survival, differentiation, and migration of climbing fiber neurons during their development in the transgenic murine inferior olivary nucleus. PMID: 17928434
14. A critical and selective role of p/CAF in PTF1-dependent gene activation during acinar differentiation. PMID: 18834332
15. Here we report a new case of cerebellar agenesis and neonatal diabetes mellitus whose parents are PTF1A mutation carriers. PMID: 19650412
16. Two separable genomic regions code for initiation and positive feedback of Ptf1a transgene expression in the developing nervous system. PMID: 19741120

Show More

Hide All

HGNC: 23734

OMIM: 607194

KEGG: hsa:256297

STRING: 9606.ENSP00000365687

UniGene: Hs.351503