PTPN23 Antibody

1. Mutations in PTPN23 gene is associated with developmental and epileptic encephalopathy. PMID: 29090338
2. HD-PTP/PTPN23 as a prominent haploinsufficient tumor suppressor gene preventing tumor progression through control of integrin trafficking. PMID: 27210750
3. the underlying mechanism of PTPN23 function in breast tumorigenesis as that of a key phosphatase that normally suppresses the activity of FYN PMID: 29066500
4. The role of HD-PTP/PTPN23 in cancer and tumorigenesis is reviewed. PMID: 28620046
5. Results present crystal structures of the coiled-coil domain of the HD-PTP phosphatase and its complex with UBAP1. The coiled-coil domain adopts an unexpected open and rigid conformation. The HD-PTP:UBAP1 structure identifies the molecular determinants of the interaction and provides a molecular basis for the specific functional cooperation between HD-PTP and UBAP1. PMID: 27839950
6. HD-PTP acts as an alternative to ESCRT-II and VPS20/CHMP6 as a link between the ESCRT-I and those ESCRT-III protein(s) necessary for ILV formation. PMID: 26221024
7. Data indicate a regulatory function of non-receptor-type tyrosine phosphatase PTPN23 in maintaining a highly phosphorylated state of survival motor neuron complex protein SMN. PMID: 25392300
8. PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR-142-3p plays an important role in the pathogenesis of testicular germ cell tumors. PMID: 23843459
9. The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR) and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from ESCRT-0 to ESCRT-III and drive EGFR sorting to intralumenal vesicles. PMID: 23477725
10. our findings suggest an evolutionarily conserved function of HDPTP-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration PMID: 22825871
11. HD-PTP degradation by calpains might result in the acquisition of a more aggressive phenotype in neoplastic cells. PMID: 22510412
12. loss of PTPN23 may increase the activity of SRC and the phosphorylation status of the E-cadherin/beta-catenin signaling complex to promote tumor growth and invasive behavior in breast cancer PMID: 21724833
13. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL PMID: 21179510
14. These results suggest that HD-PTP amounts might be regulated both at the transcriptional and post-transcriptional levels. PMID: 16408268
15. data suggest that HD-PTP might participate in modulating endothelial response to angiogenic factors and play a role in regulating the complex events leading to the formation of new vessels PMID: 16720300
16. We suggest that HD-PTP contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of FAK. PMID: 17959146
17. contributes to the regulation of endothelial migration; may play a role in angiogenesis PMID: 18762272
18. in Epidermal Growth Factor (EGF) stimulated cells, Src binds to and phosphorylates HD-PTP on tyrosine residues PMID: 18835089
19. demonstrate that HD-PTP is a catalytically inactive protein tyrosine phosphatase. As such, we identify one residue involved in its inactivation and show that colony growth reduction activity is independent of its PTP activity status in cancer cell lines PMID: 19340315

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HGNC: 14406

OMIM: 606584

KEGG: hsa:25930

STRING: 9606.ENSP00000265562

UniGene: Hs.25524