Phospho-RGS16 (Y168) Antibody

1. Data suggest that RGS16 functions as a GAP (GTPase accelerating protein) in the SCN (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW] PMID: 28502923
2. The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16. PMID: 26013170
3. suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16 PMID: 26823172
4. these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells. PMID: 25366993
5. Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses. PMID: 23248035
6. cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy. PMID: 23354309
7. Missense mutations in RGS16 gene is associated with breast cancer. PMID: 21135262
8. RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival PMID: 20571966
9. Increased RGS16 levels are associated with colorectal cancer. PMID: 19760045
10. Src mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability. PMID: 12588871
11. results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue PMID: 12642593
12. RGS16 inhibits G alpha 13-mediated, RhoA-dependent reversal of stellation and Serum Response Element activation, thus regulating G alpha 13-mediated signal transduction independently of the RGS box. PMID: 14634662
13. RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes PMID: 15998835
14. G alpha(i2) is specifically localized in human Fallopian tube epithelial cells, particularly in cilia, & is likely to have cilia-specific role in reproduction. PMID: 17347170
15. B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q). PMID: 17613536
16. Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency PMID: 17635928
17. The promoter region of RGS16 was found to be methylated in 10% human breast carcinomas PMID: 18521847
18. the loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation PMID: 19509421

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HGNC: 9997

OMIM: 602514

KEGG: hsa:6004

STRING: 9606.ENSP00000356529

UniGene: Hs.413297