Phospho-TNS1 (Y1326) Antibody

1. miR-548j functions as a metastasis-promoting miRNA to regulate breast cancer cell invasion and metastasis by targeting Tensin1 and activating Cdc42. PMID: 26949125
2. TNS1 plays an essential role in TGF-beta-induced myofibroblast differentiation. PMID: 28005397
3. TNS1, MET, and TRKC tyrosine-phosphorylated proteins are upregulated during epithelial-mesenchymal transition induced with TGF-beta, and predict the outcome in lung adenocarcinoma patients. PMID: 26216473
4. TNS1 polymorphism associated with COPD risk and lung function decline PMID: 21965014
5. data demonstrate that tensin1 is extensively phosphorylated on Ser/Thr residues in cells and phosphorylation by p38 MAPK regulates the specificity of the tensin1 Src homology 2 domain for binding to different proteins PMID: 20798394
6. The expression of tensin is increased in mesangial cells with stimulating of high concentrations of glucose. PMID: 19664390
7. Data show expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease. PMID: 20010834
8. Results suggest that PP1alpha bound to tensin1 has effects in reducing migration and invasion that are not mediated through DLC-1, and show the importance of PP1alpha binding to tensin1 for the regulation of cell polarization, migration, and invasion. PMID: 19826001
9. Tensin may play important roles in mesangial ECM production through an adhesion complex with integrin alpha5, FAK, and vinculin. PMID: 14991332
10. Results suggest that the protein-tyrosine phosphatase domain of tensin exhibits isoform-specific association with PP1alpha in a restricted spatial region of adhesions that are formed during cell migration. PMID: 17435217
11. Aged fibroblasts, generated with the Hayflick replicative senescence model, exhibit as siRNA silences fibroblasts, a reduced tensin1 expression and an impaired gel contraction capacity. PMID: 18537817
12. Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis. PMID: 19194507

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HGNC: 11973

OMIM: 600076

KEGG: hsa:7145

STRING: 9606.ENSP00000171887

UniGene: Hs.471381