Pka-C1 Antibody

Code CSB-PA318954LA01DLU
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Product Details

Full Product Name Rabbit anti-Drosophila melanogaster Pka-C1 Polyclonal antibody
Uniprot No. P12370
Target Names Pka-C1
Alternative Names Pka-C1 antibody; CdkA antibody; DC0 antibody; CG4379 antibody; cAMP-dependent protein kinase catalytic subunit 1 antibody; PKA C antibody; EC 2.7.11.11 antibody; Protein kinase DC0 antibody
Raised in Rabbit
Species Reactivity Drosophila melanogaster
Immunogen Recombinant Drosophila melanogaster cAMP-dependent protein kinase catalytic subunit 1 protein (2-353AA)
Immunogen Species Drosophila melanogaster
Conjugate Non-conjugated

The Pka-C1 Antibody (Product code: CSB-PA318954LA01DLU) is Non-conjugated. For Pka-C1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA318954LB01DLU Pka-C1 Antibody, HRP conjugated ELISA
FITC CSB-PA318954LC01DLU Pka-C1 Antibody, FITC conjugated
Biotin CSB-PA318954LD01DLU Pka-C1 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane.
Gene References into Functions
  1. Hedgehog signalling activation causes PKA to switch its substrates from Ci to Smo within the Hh signalling complex. PMID: 25289679
  2. tightly controlled dose-dependent intra-neuronal PKA activity levels are critical in determining the dendritic arbor complexity, one of the possible ways being through the regulation of organelle distribution. PMID: 25017992
  3. Alpha- NAC is a substrate of PKA following Parathyroid Hormone signaling. PMID: 24550008
  4. that manipulations that increase cAMP/PKA signaling in adipokinetic hormone (AKH)-producing cells at the base of the neuroendocrine ring gland restore the dNf1 growth deficiency. PMID: 24278035
  5. Acute expression of protein kinase A inhibitory peptide in aged animals is sufficient to reverse age-related memory impairment in wild-type animals. PMID: 21084612
  6. Two-dimensional gel electrophoresis, (32)P labelling and immunodetection show that "in vitro" PKA phosphorylates the serine in the C-terminus of the NDUFS4 subunit in isolated bovine complex I. PMID: 20433953
  7. Its signaling underlies age-related memory impairment.(review) PMID: 18646611
  8. We found that decreased PKA activity in neurons rendered flies insensitive to the wake-promoting effects of octopamine. PMID: 18799671

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Protein Families Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
Tissue Specificity More abundant in adult head than adult body.
Database Links

KEGG: dme:Dmel_CG4379

STRING: 7227.FBpp0079448

UniGene: Dm.2136

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