RAB11FIP4 Antibody

Code CSB-PA003902
Size US$100
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  • Western Blot analysis of HT29 cells using Rab11-FIP4 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
RAB11FIP4
Alternative Names
RAB11FIP4 antibody; ARFO2 antibody; KIAA1821 antibody; Rab11 family-interacting protein 4 antibody; FIP4-Rab11 antibody; Rab11-FIP4 antibody; Arfophilin-2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human Rab11-FIP4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
Gene References into Functions
  1. Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis. PMID: 29257314
  2. Our findings suggest that overexpression of Rab11-FIP4 predicts poor clinical outcomes for pancreatic cancer and contributes to pancreatic tumor progression. PMID: 28035375
  3. Results show the expression of Rab11-FIP4 upregulated in hepatocellular carcinoma (HCC) and correlated with poor prognosis. Rab11-FIP4 dramatically contributed to HCC metastasis via phosphorylation of PRAS40. PMID: 25745995
  4. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. PMID: 12470645
  5. FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst. PMID: 16148947

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Subcellular Location
Endosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle.
Tissue Specificity
Present at high level in testis (at protein level). Weakly expressed in other tissues.
Database Links

HGNC: 30267

OMIM: 611999

KEGG: hsa:84440

STRING: 9606.ENSP00000312837

UniGene: Hs.406788

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