The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).
|Gene References into Functions
- DENND3 is the exchange factor for the small GTPase Rab12 regulated through an intramolecular interaction PMID: 28249939
- a novel signaling pathway identified whereby starvation-induced activation of ULK leads to phosphorylation of endogenous DENND3, with subsequent activation of Rab12 and initiation of membrane trafficking events required for autophagy PMID: 25925668
- findings demonstrate the functional importance of Rab12 for retrograde toxin trafficking PMID: 24703428
||Recycling endosome membrane, Lipid-anchor, Cytoplasmic side, Lysosome membrane, Lipid-anchor, Cytoplasmic side, Golgi apparatus membrane, Cytoplasmic vesicle, autophagosome
||Small GTPase superfamily, Rab family