RAB3GAP2 Antibody, HRP conjugated

Code CSB-PA872480LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RAB3GAP2 Polyclonal antibody
Uniprot No.
Target Names
RAB3GAP2
Alternative Names
RAB3GAP2 antibody; KIAA0839 antibody; Rab3 GTPase-activating protein non-catalytic subunit antibody; RGAP-iso antibody; Rab3 GTPase-activating protein 150 kDa subunit antibody; Rab3-GAP p150 antibody; Rab3-GAP150 antibody; Rab3-GAP regulatory subunit antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rab3 GTPase-activating protein non-catalytic subunit protein (277-387AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Gene References into Functions
  1. functionally severe RAB3GAP2 mutations cause Warburg Micro syndrome while hypomorphic RAB3GAP2 mutations can result in the milder Martsolf phenotype PMID: 20967465
  2. Data show that at chemical synapses, Rab3 performs specific functions in synpatic vesicle exocytosis. PMID: 18485483
  3. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner through MADD. PMID: 18849981
Involvement in disease
Martsolf syndrome (MARTS); Warburg micro syndrome 2 (WARBM2)
Subcellular Location
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
Protein Families
Rab3-GAP regulatory subunit family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 17168

OMIM: 212720

KEGG: hsa:25782

STRING: 9606.ENSP00000351832

UniGene: Hs.654849

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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