RAB3GAP2 Antibody

Datasheet

Code	CSB-PA872480LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: 293 whole cell lysate All lanes: RAB3GAP2 antibody at 5μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 156, 24 kDa Observed band size: 110, 130, 150 kDa IHC image of CSB-PA872480LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA872480LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB3GAP2 Polyclonal antibody

Uniprot No.

Q9H2M9

Target Names

RAB3GAP2

Alternative Names

RAB3GAP2 antibody; KIAA0839 antibody; Rab3 GTPase-activating protein non-catalytic subunit antibody; RGAP-iso antibody; Rab3 GTPase-activating protein 150 kDa subunit antibody; Rab3-GAP p150 antibody; Rab3-GAP150 antibody; Rab3-GAP regulatory subunit antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Rab3 GTPase-activating protein non-catalytic subunit protein (277-387AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RAB3GAP2 Antibody (Product code: CSB-PA872480LA01HU) is Non-conjugated. For RAB3GAP2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA872480LB01HU	RAB3GAP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA872480LC01HU	RAB3GAP2 Antibody, FITC conjugated
Biotin	CSB-PA872480LD01HU	RAB3GAP2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

Gene References into Functions

functionally severe RAB3GAP2 mutations cause Warburg Micro syndrome while hypomorphic RAB3GAP2 mutations can result in the milder Martsolf phenotype PMID: 20967465
Data show that at chemical synapses, Rab3 performs specific functions in synpatic vesicle exocytosis. PMID: 18485483
KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner through MADD. PMID: 18849981

Involvement in disease

Martsolf syndrome (MARTS); Warburg micro syndrome 2 (WARBM2)

Subcellular Location

Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.

Protein Families

Rab3-GAP regulatory subunit family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 17168

OMIM: 212720

KEGG: hsa:25782

STRING: 9606.ENSP00000351832

UniGene: Hs.654849

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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