RAB6C Antibody

Code CSB-PA003897
Size US$100
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  • Western Blot analysis of COLO205 cells using Rab 6C Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
RAB6C
Alternative Names
RAB 6C antibody; Rab6 like protein WTH3 antibody; Rab6-like protein WTH3 antibody; RAB6C antibody; RAB6C member RAS oncogene family antibody; RAB6C_HUMAN antibody; Ras related protein Rab 6C antibody; Ras-related protein Rab-6C antibody; WTH3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Rab 6C.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in the regulation of centrosome duplication and cell cycle progression.
Gene References into Functions
  1. Rab6A'(Q72L) was then purified to homogeneity and crystallized at 293 K. X-ray diffraction data were collected to a resolution of 1.9 A from a crystal belonging to space group P22(1)2(1) with unit-cell parameters a = 36.84, b = 96.78, c = 109.99 A PMID: 22949199
  2. RAB6C is a rare example of a recently emerged retrogene that has acquired the status of a new gene, encoding a functional protein with altered characteristics compared to Rab6A'. PMID: 20064528
  3. The behavior of WTH3 in primary drug-resistant breast cancer epithelial cells was similar to that in a model system where epigenetic regulation of the WTH3 gene was linked to the MDR phenotype. PMID: 16267028
  4. The negative role played by the WTH3 gene in MDR development is through its proapoptotic potential that is regulated by multiple mechanisms at the transcription level, and one of these mechanisms is linked to the p53 gene. PMID: 17426708
  5. plays role in multi-drug resistance development;DNA methylation is one of its transcription regulatory mechanisms PMID: 18992151

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Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families
Small GTPase superfamily, Rab family
Tissue Specificity
Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP
Database Links

HGNC: 16525

OMIM: 612909

KEGG: hsa:84084

STRING: 9606.ENSP00000387307

UniGene: Hs.591552

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