RABAC1 Antibody

Code CSB-PA019227GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RABAC1
Alternative Names
RABAC1; PRA1; PRAF1; Prenylated Rab acceptor protein 1; PRA1 family protein 1
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RABAC1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Gene References into Functions
  1. Results suggest that NDRG2 and prenylated Rab acceptor-1 (PRA1) might act synergistically to prevent signaling of T-cell facto/beta-catenin. PMID: 23068607
  2. Prenylated Rab acceptor protein 1 (PRA1) was identified as an interacting partner of SNCA. PMID: 21798244
  3. These findings delineated novel roles of PRA1 in lipid transport and cell migration. PMID: 20592422
  4. findings show Yip3 acts catalytically to dissociate complexes of endosomal Rabs bound to GDI and to deliver them onto membranes; propose that the conserved Yip proteins serve as GDI-displacement factors for the targeting of Rab GTPases in eukaryotic cells PMID: 14574414
  5. Coexpression of a PRA1 export mutant or knockdown of PRA1 led to redistribution of LMP1 and its associated signaling molecules to the endoplasmic reticulum and subsequent impairment of LMP1-induced NF-kappaB activation. PMID: 16917502
  6. in vivo modulation of PRA1 may be involved in TCF/beta-catenin signaling, as well as cellular proliferation and tumorigenesis PMID: 16930546

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein Families
PRA1 family
Tissue Specificity
Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.
Database Links

HGNC: 9794

OMIM: 604925

KEGG: hsa:10567

STRING: 9606.ENSP00000222008

UniGene: Hs.11417

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