RARG Antibody

Code CSB-PA019340LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, Mouse kidney tissue
    All lanes: RARG antibody at 8µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 51, 50, 43, 48 kDa
    Observed band size: 51 kDa

  • IHC image of CSB-PA019340LA01HU diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RARG Polyclonal antibody
Uniprot No.
Target Names
RARG
Alternative Names
NR1B3 antibody; Nuclear receptor subfamily 1 group B member 3 antibody; RAR gamma antibody; RAR gamma isoform 2 antibody; RAR gamma2 antibody; RAR-gamma antibody; RARC antibody; Rarg antibody; RARG_HUMAN antibody; retinoic acid nuclear receptor gamma variant 1 antibody; retinoic acid nuclear receptor gamma variant 2 antibody; Retinoic acid receptor gamma antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Retinoic acid receptor gamma protein (13-87AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RARG Antibody (Product code: CSB-PA019340LA01HU) is Non-conjugated. For RARG Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA019340LB01HU RARG Antibody, HRP conjugated ELISA
FITC CSB-PA019340LC01HU RARG Antibody, FITC conjugated
Biotin CSB-PA019340LD01HU RARG Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
Gene References into Functions
  1. Study reports that retinoic acid receptor-gamma (RARgamma) is a negative regulator of p53 signaling and thus extend the oncogenic potential of RARgamma to a new role in controlling the balance between AKT and p53. PMID: 28336971
  2. the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked. PMID: 28871172
  3. Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC) tissues and demonstrate that RARgamma could promote HCC invasion and metastasis by regulating E-cadherin reduction. PMID: 27756432
  4. Our study is the first to report that treatment with a RARgamma specific agonist augments cellular adhesion to alpha5beta1 integrin substrates, increases cell surface levels of the beta1 integrin subunit, and dampens cellular proliferation in a time and concentration dependent manner in a human erythroleukemia cell line PMID: 28552962
  5. Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis. PMID: 27325643
  6. RARgamma might serve as a potential therapeutic target for chemoresistant colorectal cancer patients. PMID: 28272990
  7. A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers. PMID: 26237429
  8. deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98-RARG-mediated transformation PMID: 25510432
  9. RARgamma in concert with ATRA regulates protein levels of CDK1 and its subcellular localization. PMID: 23518499
  10. RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt/NF-kappaB and Wnt/beta-catenin pathways. PMID: 23798555
  11. Low RARgamma expression is associated with advanced gastric cancer. PMID: 22901127
  12. Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene. PMID: 22362749
  13. findings demonstrate that signaling through RARs has critical roles in molecular reprogramming and that the synergistic interaction between Rarg and Lrh1 directs reprogramming toward ground-state pluripotency PMID: 21990348
  14. results suggest that a RARgamma-dependent functional crosstalk is present between the retinoic acid and BMP2 signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells PMID: 21401418
  15. Microbiota are required for the generation of both IL-17-positive and Foxp3-positive, retinoic acid-related orphan receptor gamma-positive transgenic T cell subsets in the intestinal lamina propria. PMID: 21178008
  16. PARgamma expressions are decreased in PBMC and SWAT of obese subjects in weight gain. PMID: 20387030
  17. Retinoic acid receptor gamma 2 could specifically interact with vitamin D response elements, either in the presence or absence of the vitamin D receptor. PMID: 20420906
  18. Retinoid signaling is attenuated by retinoic acid-induced proteasome-mediated degradation of RARG in human keratocytes. PMID: 11855864
  19. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. PMID: 12189556
  20. The 1.4 A resolution crystal structure of the ligand binding domain of the retinoic acid receptor RARgamma complexed with the retinoid SR11254 reveals several types of C-H...O hydrogen bonds PMID: 12220491
  21. Present throughout the epithelium with minimal nuclear accumulation. Increased in basal and luminal epithelial nuclei in glands with benign prostatic hyperplasia. PMID: 12399530
  22. RARgamma interact only weakly with SMRT. PMID: 12554770
  23. In a 9-cis retinoic acid-dependent fashion in cells in vitro, retinoic acid receptor isoform gamma stimulates the expression of reporter constructs containing the site that binds aldehyde dehydrogenase-2. PMID: 14691372
  24. Tazarotene is a prodrug selective for RARbeta/gamma, thereby motivating interest in determining whether tazarotene might activate putative tumor suppressor activity. PMID: 15383624
  25. phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
  26. study elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation PMID: 17325034
  27. analysis to determine directly whether PML-RAR, like PML-RAR, is able to induce APL PMID: 18685608
  28. The first 2250 bp of the HAS2 promoter contain three response elements (REs) for the transcription factor CREB1 as well as two REs for the nuclear receptor RAR PMID: 19416972
  29. the subcellular localization of RARgamma is regulated by complex interactions among ligand binding, receptor phosphorylation, and receptor dimerizations PMID: 19416983

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Nuclear hormone receptor family, NR1 subfamily
Tissue Specificity
Expressed in aortic endothelial cells (at protein level).
Database Links

HGNC: 9866

OMIM: 180190

KEGG: hsa:5916

STRING: 9606.ENSP00000377947

UniGene: Hs.1497

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