RARRES1 Antibody

1. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. PMID: 29902837
2. Data demonstrated that RARRES1 expression is lost in choriocarcinoma tumors due to promotor hypermethylation. Also, further results hypothesized that RARRES1 might be a negative regulator of EMT through induction of contact inhibition. PMID: 29169400
3. Data show that retinoic acid receptor responder 1 (RARRES1) expression is subtype-dependent and regulated by DNA methylation and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3). PMID: 27286452
4. Data suggest that Retinoic Acid Receptor Responder (RARRES1)/ Tazarotene-induced gene-1 (TIG-1) may serve as a target for therapeutic intervention both in cancer and in angiogenesis-related disorders. PMID: 28678839
5. Authors found that transmembrane protein 192 (TMEM192) interacted with TIG1. Authors also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins. PMID: 27989102
6. All-trans retinoic acid modulated secretion of RARRES1 in a dose dependent manner. PMID: 22942771
7. our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in hepatocellular carcinoma . PMID: 24006221
8. High TIG1 expression is associated with inflammatory breast cancer through activation of Axl kinase. PMID: 24014597
9. Analysis of a standard liver fibrosis model (CCl(4)) demonstrated an early induction of RARRES1 mRNA and protein expression. PMID: 22669512
10. genotype-associated hypermethylation of the ETS-family target gene RARRES1 influences methylation at its neighbor gene LXN and could be useful as a prognostic biomarker. PMID: 22573467
11. Knocking-down CTCF expression hampered RARRES1 expression. PMID: 22615834
12. TIG1 suppressed PGE2-stimulated Wnt and cAMP signaling pathways in colon cancer cells through GRK5. PMID: 22126303
13. GRK5 mediates cell growth suppression by TIG1A. Thus, TIG1 may participate in the downregulation of G-protein coupled signaling by upregulating GRK5 expression. PMID: 21575264
14. The results of this study suggested that short RAI1 alleles might be releated to schizophreina disease. PMID: 21168224
15. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis. PMID: 21303978
16. Silencing of TIG1 promoter by hypermethylation is common in human cancers and may contribute to the loss of retinoic acid responsiveness in some neoplastic cells. PMID: 15059893
17. Hypermethylation of tazarotene-induced gene 1 is associated with gastric carcinogenesis PMID: 16134180
18. TIG1 overexpression in SASC inhibited their differentiation into osteocytes and the expression of osteocalcin PMID: 19250291
19. Findings suggest that TIG1 may play a role in cellular proliferation and invasion in NPC cells and that its function may be dependent on the EBV status. PMID: 19737656
20. TIG1 undergoes frequent epigenetic inactivation due to aberrant DNA hypermethylation in gastric cancers. PMID: 19806788

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HGNC: 9867

OMIM: 605090

KEGG: hsa:5918

STRING: 9606.ENSP00000237696

UniGene: Hs.131269