RARS2 Antibody

Code CSB-PA732918LA01HU
Size US$166
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Image
  • IHC image of CSB-PA732918LA01HU diluted at 1:200 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RARS2 Polyclonal antibody
Uniprot No.
Target Names
RARS2
Alternative Names
Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS), RARS2, RARSL
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Probable arginine--tRNA ligase, mitochondrial protein (230-578aa)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RARS2 Antibody (Product code: CSB-PA732918LA01HU) is Non-conjugated. For RARS2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA732918LB01HU RARS2 Antibody, HRP conjugated ELISA
FITC CSB-PA732918LC01HU RARS2 Antibody, FITC conjugated
Biotin CSB-PA732918LD01HU RARS2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. Characteristic neuroradiological abnormalities of PCH6 such as vermis and cerebellar hypoplasia and progressive pontocerebellar atrophy may be missing in patients with RARS2 mutations PMID: 27769281
  2. RARS2 gene mutations can cause a metabolic neurodegenerative disease manifesting primarily as early onset epileptic encephalopathies with post-natal microcephaly, without pontocerebellar hypoplasia. PMID: 26970947
  3. Mutations in the RARS2 promoter are likely to represent a new causal mechanism of pontocerebellar hypoplasia. PMID: 25809939
  4. Molecular investigations of RARS2 disclosed the c.25A>G/p.I9V and the c.1586+3A>T in family A. PMID: 22569581
  5. mutations in the gene encoding mitochondrial arginyl-tRNA synthetase, RARS2, may have a role in pontocerebellar hypoplasia type 6 [case report] PMID: 22086604

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Involvement in disease
Pontocerebellar hypoplasia 6 (PCH6)
Subcellular Location
Mitochondrion matrix.
Protein Families
Class-I aminoacyl-tRNA synthetase family
Database Links

HGNC: 21406

OMIM: 611523

KEGG: hsa:57038

STRING: 9606.ENSP00000358549

UniGene: Hs.485910

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