RASEF Antibody

Code CSB-PA019356GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RASEF
Alternative Names
RASEF antibody; RAB45 antibody; Ras and EF-hand domain-containing protein antibody; Ras-related protein Rab-45 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human RASEF
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.
Gene References into Functions
  1. Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. PMID: 24703243
  2. overexpression of RAB45 increased the phosphorylation levels of p38, resulting in the induction of apoptosis and inhibition of proliferation of CML progenitor cells PMID: 21890458
  3. Homozygosity, in combination with methylation, appears to be the mechanism targeting RASEF in uveal melanoma, and allelic imbalance at this locus supports a TSG role for RASEF. PMID: 18385040
Subcellular Location
Cytoplasm, perinuclear region.
Protein Families
Small GTPase superfamily, Rab family
Tissue Specificity
Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
Database Links

HGNC: 26464

OMIM: 611344

KEGG: hsa:158158

STRING: 9606.ENSP00000365630

UniGene: Hs.129136

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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