RASSF4 Antibody

Code CSB-PA019376GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RASSF4
Alternative Names
3830411C14Rik antibody; AD037 antibody; AI586137 antibody; MGC105606 antibody; MGC44914 antibody; OTTHUMP00000019493 antibody; Ras association (RalGDS/AF 6) domain family 4 antibody; Ras association (RalGDS/AF 6) domain family member 4 antibody; Ras association domain containing protein 4 antibody; Ras association domain family 4 antibody; Ras association domain-containing protein 4 antibody; RASF4_HUMAN antibody; RASSF 4 antibody; Rassf4 antibody; RP11-285G1.4 antibody; Tumor suppressor RASSF4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human RASSF4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
Gene References into Functions
  1. RASSF4 controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes. PMID: 28600435
  2. RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma cells. PMID: 28081736
  3. the present study suggested that RASSF4 serves as an important tumor suppressor in human nonsmall cell lung cancer . PMID: 26526576
  4. RASSF4 promotes EV71 replication and the production of viral progeny to accelerate the inhibition of the phosphorylation of AKT. PMID: 25701784
  5. expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
  6. Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia. PMID: 19066393

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Tissue Specificity
Widely expressed. Frequently down-regulated in tumor cell lines.
Database Links

HGNC: 20793

OMIM: 610559

KEGG: hsa:83937

STRING: 9606.ENSP00000339692

UniGene: Hs.522895

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