RASSF7 Antibody, HRP conjugated

Datasheet

Code	CSB-PA863596LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RASSF7 Polyclonal antibody

Uniprot No.

Q02833

Target Names

RASSF7

Alternative Names

C11orf13 antibody; Chromosome 11 open reading frame 13 antibody; HRAS1 antibody; HRAS1 related cluster 1 antibody; HRAS1 related cluster protein 1 antibody; HRAS1-related cluster protein 1 antibody; HRC1 antibody; MGC126069 antibody; MGC126070 antibody; Ras association (RalGDS/AF 6) domain family (N terminal) member 7 antibody; Ras association (RalGDS/AF 6) domain family 7 antibody; Ras association domain containing protein 7 antibody; Ras association domain-containing protein 7 antibody; RASF7_HUMAN antibody; RASSF 7 antibody; RASSF7 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ras association domain-containing protein 7 protein (300-368AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

Gene References into Functions

RASSF7 promotes cell proliferation through activating MEK1/MEK2-ERK1/ERK2 signaling pathway in hepatocellular carcinoma. PMID: 29729697
Suggest that loss of RASSF7 expression results in apoptosis in nucleus pulposus cells in human intervertebral disc degeneration. PMID: 26884887
truncated RASSF7 could act as an oncogene in a small subset of tumours where it is mutated in this way. PMID: 26569555
The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. PMID: 22695170
RASSF7 acts in concert with N-Ras to constitute a stress-sensitive temporary mechanism of apoptotic regulation. PMID: 21278800
RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. PMID: 20629633
rare alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident PMID: 15098441

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Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.

Database Links

HGNC: 1166

OMIM: 143023

KEGG: hsa:8045

STRING: 9606.ENSP00000344226

UniGene: Hs.72925

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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