RASSF7 Antibody

Code CSB-PA019379GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RASSF7
Alternative Names
C11orf13 antibody; Chromosome 11 open reading frame 13 antibody; HRAS1 antibody; HRAS1 related cluster 1 antibody; HRAS1 related cluster protein 1 antibody; HRAS1-related cluster protein 1 antibody; HRC1 antibody; MGC126069 antibody; MGC126070 antibody; Ras association (RalGDS/AF 6) domain family (N terminal) member 7 antibody; Ras association (RalGDS/AF 6) domain family 7 antibody; Ras association domain containing protein 7 antibody; Ras association domain-containing protein 7 antibody; RASF7_HUMAN antibody; RASSF 7 antibody; RASSF7 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RASSF7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Gene References into Functions
  1. RASSF7 promotes cell proliferation through activating MEK1/MEK2-ERK1/ERK2 signaling pathway in hepatocellular carcinoma. PMID: 29729697
  2. Suggest that loss of RASSF7 expression results in apoptosis in nucleus pulposus cells in human intervertebral disc degeneration. PMID: 26884887
  3. truncated RASSF7 could act as an oncogene in a small subset of tumours where it is mutated in this way. PMID: 26569555
  4. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. PMID: 22695170
  5. RASSF7 acts in concert with N-Ras to constitute a stress-sensitive temporary mechanism of apoptotic regulation. PMID: 21278800
  6. RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. PMID: 20629633
  7. rare alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident PMID: 15098441

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.
Database Links

HGNC: 1166

OMIM: 143023

KEGG: hsa:8045

STRING: 9606.ENSP00000344226

UniGene: Hs.72925

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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