RBM4 Antibody

1. The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells. PMID: 28276498
2. hese findings suggest that RBM4 is a new biomarker in gastric cancer, as the reduced expression of this protein is correlated with poor differentiation, lymph node status and distant metastasis PMID: 27324405
3. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway. PMID: 29138007
4. TPM1-AS regulates the alternative splicing of TPM1 through an interaction with RBM4 and involves in TPM1-mediated filopodium formation and migration of cancer cells PMID: 28754317
5. RBM4 is induced and is involved in the PKM splicing switch and neuronal gene expression during hypoxia-induced neuronal differentiation. PMID: 27821480
6. alternative splicing patterns were altered by knockdown of RBM4 in several types of neoplasms PMID: 26898347
7. Loss of RBM4 expression is associated with colorectal cancer. PMID: 26506517
8. The results indicate that the alanine-rich C-terminal domain, in conjunction with its conjoined RNA-binding domain(s), differentially influences the subnuclear localization and biogenesis of RBM4. PMID: 25414336
9. Up-regulation of RBM4 is associated with breast cancer. PMID: 25140042
10. RBM4 is a tumor suppressor with therapeutic potential and clinical values as a prognostic factor. PMID: 25203323
11. we propose the emerging role of RBM4 in regulating the adipocyte-specific splicing events and transcription cascade, which subsequently facilitate the development and function of brown adipocyte-like cells. PMID: 24389249
12. role in negative feed-forward loop that disrupts inflammattory cytokine translation following Toll-like receptor 4 response PMID: 23897118
13. RBM4 homologs exert different effects on 5' splice site utilization and exon selection, and exhibit different subnuclear localization patterns. PMID: 23527094
14. Data show that RBM4 interacts directly with Ago2 during muscle cell differentiation and may recruit Ago2 to suppress translation of target mRNAs. PMID: 19801630
15. Data show that the nuclear matrix protein matrin 3, cytoskeletal motor protein HMP, and the circadian clock protein lark were significantly decreased in fetal Down syndrome brain. PMID: 12469345
16. the regulated alternative splicing of alpha-TM by the antagonistic splicing regulators RBM4 and PTB PMID: 16260624
17. RBM4 is expressed in the human brain regions affected in tauopathy, including the hippocampus and frontal cortex. RBM4 is involved in tau exon 10 alternative splicing PMID: 16777844
18. Wilms tumor 1 protein, WT1 interacts with the novel splicing regulator RBM4, the longer isoform of WT1 is able to inhibit the effect of RBM4 on alternative splicing. PMID: 16934801
19. a previously unrecognized paradigm for the RNA-binding protein RBM4 in its phosphorylation-modulated dual action as a suppressor of cap-dependent and enhancer of IRES-mediated translation in response to stress signals PMID: 17284590
20. human brain, expression of RBM4a was strongly up-regulated in cerebellum as compared to forebrain. PMID: 18708123
21. RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing. PMID: 18723113
22. The alternative splicing imbalance of CoAA and RBM4, because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation PMID: 19416963

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HGNC: 9901

OMIM: 602571

KEGG: hsa:5936

STRING: 9606.ENSP00000425446

UniGene: Hs.523822