RBM45 Antibody, FITC conjugated

1. Results suggest that RBM45 serves as a negative regulator to prevent FUS-mediated excessive recruitment of HDAC1 to the sites of DNA damage. PMID: 29140459
2. Analysis of the biological processes and pathways associated with RBM45-interacting proteins indicates enrichment for nuclear RNA processing/splicing via association with hnRNP proteins and cytoplasmic RNA translation via eiF2 and eiF4 pathways. PMID: 26979993
3. using an in vitro cellular model, we demonstrated that Drb1 co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43 PMID: 27226551
4. RMB45 may function as a homo-oligomer and that its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation. PMID: 26391765
5. Data indicate that RNA binding protein RBM45/Kelch-like ECH-associated protein 1 (KEAP1) interactions in amyotrophic lateral sclerosis (ALS) spinal cord. PMID: 25939382
6. This study demonistrated that RBM45 protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. PMID: 22993125
7. a new member of RRM-type neural RNA-binding protein PMID: 12220514

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HGNC: 24468

OMIM: 608888

KEGG: hsa:129831

STRING: 9606.ENSP00000286070

UniGene: Hs.377257