RBM45 Antibody

Datasheet

Code	CSB-PA814203LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat brain tisseu, Rat heart tissue All lanes: RBM45 antibody at 12μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 54, 38 kDa Observed band size: 54 kDa Immunofluorescence staining of HepG2 cells with CSB-PA814203LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RBM45 Polyclonal antibody

Uniprot No.

Q8IUH3

Target Names

RBM45

Alternative Names

Developmentally-regulated RNA-binding protein 1 antibody; DRB1 antibody; FLJ44612 antibody; MGC42237 antibody; Putative RNA binding protein RB 1 antibody; RB-1 antibody; RBM45 antibody; RBM45_HUMAN antibody; RNA-binding motif protein 45 antibody; RNA-binding protein 45 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human RNA-binding protein 45 protein (170-244AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RBM45 Antibody (Product code: CSB-PA814203LA01HU) is Non-conjugated. For RBM45 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA814203LB01HU	RBM45 Antibody, HRP conjugated	ELISA
FITC	CSB-PA814203LC01HU	RBM45 Antibody, FITC conjugated
Biotin	CSB-PA814203LD01HU	RBM45 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

Gene References into Functions

Results suggest that RBM45 serves as a negative regulator to prevent FUS-mediated excessive recruitment of HDAC1 to the sites of DNA damage. PMID: 29140459
Analysis of the biological processes and pathways associated with RBM45-interacting proteins indicates enrichment for nuclear RNA processing/splicing via association with hnRNP proteins and cytoplasmic RNA translation via eiF2 and eiF4 pathways. PMID: 26979993
using an in vitro cellular model, we demonstrated that Drb1 co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43 PMID: 27226551
RMB45 may function as a homo-oligomer and that its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation. PMID: 26391765
Data indicate that RNA binding protein RBM45/Kelch-like ECH-associated protein 1 (KEAP1) interactions in amyotrophic lateral sclerosis (ALS) spinal cord. PMID: 25939382
This study demonistrated that RBM45 protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. PMID: 22993125
a new member of RRM-type neural RNA-binding protein PMID: 12220514

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Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.

Database Links

HGNC: 24468

OMIM: 608888

KEGG: hsa:129831

STRING: 9606.ENSP00000286070

UniGene: Hs.377257

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Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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