RBP3 Antibody, FITC conjugated

Code CSB-PA019482LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RBP3 Polyclonal antibody
Uniprot No.
Target Names
RBP3
Alternative Names
D10S64 antibody; D10S65 antibody; D10S66 antibody; Interphotoreceptor retinoid binding protein antibody; Interphotoreceptor retinoid-binding protein antibody; Interstitial retinol binding protein antibody; Interstitial retinol-binding protein antibody; IRBP antibody; RBP 3 antibody; rbp3 antibody; RBPI antibody; RET3_HUMAN antibody; Retinol binding protein 3 antibody; Retinol binding protein 3 interstitial antibody; Retinol-binding protein 3 antibody; RP66 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Retinol-binding protein 3 protein (1146-1246AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
Gene References into Functions
  1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function. PMID: 25766589
  2. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
  3. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. PMID: 23882694
  4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
  5. The mouse retina promotes cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles. PMID: 21613504
  6. Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration. PMID: 19823802
  7. studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 PMID: 15713799
  8. analysis of IRBP proteolysis is useful as a biomarker for uveitis PMID: 18266969
  9. Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa. PMID: 19074801
  10. In interphotoreceptor retinoid-binding protein transgenic mice cone dysfunction appears to be caused by abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore without IRBP. PMID: 19193895

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Involvement in disease
Retinitis pigmentosa 66 (RP66)
Subcellular Location
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
Protein Families
Peptidase S41A family
Database Links

HGNC: 9921

OMIM: 180290

KEGG: hsa:5949

STRING: 9606.ENSP00000224600

UniGene: Hs.591928

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