RBP3 Antibody

1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function. PMID: 25766589
2. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
3. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. PMID: 23882694
4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
5. The mouse retina promotes cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles. PMID: 21613504
6. Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration. PMID: 19823802
7. studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 PMID: 15713799
8. analysis of IRBP proteolysis is useful as a biomarker for uveitis PMID: 18266969
9. Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa. PMID: 19074801
10. In interphotoreceptor retinoid-binding protein transgenic mice cone dysfunction appears to be caused by abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore without IRBP. PMID: 19193895

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HGNC: 9921

OMIM: 180290

KEGG: hsa:5949

STRING: 9606.ENSP00000224600

UniGene: Hs.591928