RFX1 Antibody

1. RFX1 interacts with the D sequence of adeno-associated virus inverted terminal repeat and regulates AAV transduction. PMID: 29317724
2. RFX1 expression was significantly lower in HCC tissues compared to the corresponding non-tumor tissues. In vitro studies suggested that knocking down RFX1 facilitated HCC cell invasion, while overexpression of RFX1 reduced the invasion of HCC cells. RFX1 regulated expression of some epithelial-mesenchymal transition markers. PMID: 29764705
3. Findings indicate that RFX1 functions downstream of STAT3 and phosphorylated STAT3 can inhibit RFX1 expression and suggest a unique role for RFX1 in Th17-related autoimmune diseases. PMID: 29422534
4. Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging. PMID: 28003160
5. induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes PMID: 27451412
6. Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1). PMID: 27283392
7. therapeutic targets for childhood severe asthmatics identified thru DNA microarray PMID: 25979195
8. Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells. PMID: 24952874
9. regulatory factor 1 directly regulates CD44 expression in glioblastoma PMID: 24526308
10. Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs. PMID: 22415835
11. RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription. PMID: 22582395
12. NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis-regulatory elements. PMID: 22490869
13. RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4(+) T cells, thereby regulating local H3K9 tri-methylation levels. PMID: 21192791
14. regulates autoimmunity via epigenetic modifications in T cells of systemic lupus erythematosus patients PMID: 20223637
15. We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transc PMID: 20381594
16. RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter. PMID: 20189986
17. Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells. PMID: 12411430
18. Disruption of the RFX site within 263P blunts repressor activity in transfected GC cells; however, repression is only abolished when both PSE-A/RFX and PSE-B/NF-1 sites are mutated. PMID: 12624117
19. novel role for the RFX family of transcription factors as modulators of Ras signalling in epithelial cells PMID: 15024578
20. RFX1 gene may be epigenetically silenced in human gliomas and involved in glioma tumorigenesis. PMID: 15334059
21. Six novel S'-Y' regulatory modules have been identified that are controlled by the human major histocompatibility class II-specific regulatory factor RFX complex. PMID: 15528357
22. evidence for a common mechanism for Crt1 and Rfx1 expression and for the conservation of their mode of action in response to a DNA replication block in yeasts and humans PMID: 16287876
23. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I. PMID: 16289097
24. results demonstrate that RFX1 and RFX5 differentially interact with class I HDACs underlying the different pathways when repressing collagen synthesis PMID: 16464847
25. RFX1 mediates the immediate early response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells. PMID: 17630394
26. RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene. PMID: 19334528
27. RFX and/or enhanceosome assembly plays a key role independent of transcriptional coactivator CIITA in protecting major histocompatibility class II antigen promoters against DNA methylation. PMID: 19620312

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HGNC: 9982

OMIM: 600006

KEGG: hsa:5989

STRING: 9606.ENSP00000254325

UniGene: Hs.655215