RGS7 Antibody

1. Results found that RGS7 was mutated in 11% of melanomas with three recurrent mutations (p.R44C, p.E383K and p.R416Q). p.R44C was shown to destabilize the protein due to the loss of an H-bond and salt bridge. RGS7 p.R44C has weaker catalytic activity for its substrate Galphao, thus providing a dual mechanism for its loss of function resulting in increase anchorage-independent growth, migration and invasion of melanoma c... PMID: 29330521
2. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) PMID: 28432124
3. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7. PMID: 26895961
4. Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval PMID: 26113603
5. New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. PMID: 23054467
6. the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. PMID: 23857581
7. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. PMID: 21343290
8. tumor necrosis factor-alpha regulates the interaction of RGS7 with 14-3-3 PMID: 12077120
9. could play a role in synaptic vesicle exocytosis through its interaction with snapin PMID: 12659861
10. Galpha-regulated plasma membrane localization and palmitoylation of RGS7. PMID: 15496508
11. cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. PMID: 16867977
12. The DEP domain of RGS7 can directly bind to the third intracellular loop of the M3R and attenuate receptor-induced Ca2+ mobilization in a M3 subtype-selective manner. PMID: 19182865
13. cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way PMID: 19376773
14. common variation within the RGS7 locus may be involved in multiple sclerosis susceptibility. PMID: 19626040

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HGNC: 10003

OMIM: 602517

KEGG: hsa:6000

STRING: 9606.ENSP00000355523

UniGene: Hs.655739