RGS9 Antibody

1. This case series highlights the clinical presentations and features of 5 affected children (3 Arab families) who harbored the same homozygous RGS9 frameshift mutation, which seems to represent a founder effect for the Arabian Peninsula. PMID: 29107794
2. To identify single-nucleotide polymorphisms that contribute to the genetic susceptibility to schizophrenia, we examined the potential association between schizophrenia and 9 single nucleotide polymorphisms in the G-protein signaling 9 gene PMID: 26345773
3. These findings indicate a role for RGS9 gene polymorphisms in heroin dependence and may be informative for future genetic or biological studies on heroin dependence. PMID: 25591550
4. the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. PMID: 23857581
5. These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight. PMID: 22132185
6. beta-Arrestin2 is required for the inhibition of D3R signaling by RGS9-2. PMID: 22006018
7. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors PMID: 21511947
8. The main goal of this review is to illustrate how various functions are fulfilled through the interplay between the intrinsic molecular properties of RGS9 isoforms. PMID: 20374717
9. The expression of RGS9-2 inhibits dopamine-mediated cellular internalization of the dopamine 2 (D2) receptor. PMID: 20477943
10. no association with schizophrenia in an Israeli Jewish population PMID: 20016399
11. This is the first report describing a nonsense mutation in RGS9. PMID: 19818506
12. five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones PMID: 14702087
13. under certain conditions, RGS9 and Gbeta5 may possibly function as betagamma dimer PMID: 15474482
14. homozygous mutations in RGS9 gene that encodes the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identifird in patients with bradyopsia. PMID: 17698770
15. In the haplotype analysis, a significant association of the AGG haplotype (rs8077696-rs8070231-rs2292593) of the RGS9 gene was found (permutation P = 0.007) PMID: 18548510

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HGNC: 10004

OMIM: 604067

KEGG: hsa:8787

STRING: 9606.ENSP00000262406

UniGene: Hs.664380