RIN3 Antibody

Datasheet

Code	CSB-PA019728LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA019728LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RIN3 Polyclonal antibody

Uniprot No.

Q8TB24

Target Names

RIN3

Alternative Names

RIN3 antibody; Ras and Rab interactor 3 antibody; Ras interaction/interference protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ras and Rab interactor 3 protein (245-465AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RIN3 Antibody (Product code: CSB-PA019728LA01HU) is Non-conjugated. For RIN3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA019728LB01HU	RIN3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019728LC01HU	RIN3 Antibody, FITC conjugated
Biotin	CSB-PA019728LD01HU	RIN3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

Gene References into Functions

RIN3 may be involved in endolysosomal transport-a process known to be important to development of early onset AD. PMID: 28738127
RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function. PMID: 25701875
discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3 PMID: 26296892
The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease. PMID: 24945404
RIN3 is a negative regulator of mast cell responses to SCF PMID: 23185384
RIN3 specifically acts as a GEF for Rab31. PMID: 21586568
RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes PMID: 12972505
Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles. PMID: 18486601

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Subcellular Location

Cytoplasm. Cytoplasmic vesicle. Early endosome.

Protein Families

RIN (Ras interaction/interference) family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 18751

OMIM: 610223

KEGG: hsa:79890

STRING: 9606.ENSP00000216487

UniGene: Hs.326822

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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