RIOK3 Antibody

Datasheet

Code	CSB-PA570953
Size	US$297
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Image	Western blot analysis of extracts from HepG2 cells, using RIOK3 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RIOK3 Polyclonal antibody

Uniprot No.

O14730

Target Names

RIOK3

Alternative Names

Homolog of the Aspergillus nidulans sudD gene product antibody; RIO kinase 3 (yeast) antibody; RIO kinase 3 antibody; RIOK3 antibody; RIOK3_HUMAN antibody; Serine/threonine protein kinase RIO3 antibody; Serine/threonine-protein kinase RIO3 antibody; SudD (suppressor of bimD6; Aspergillus nidulans) homolog antibody; SUDD antibody; sudD homolog antibody; SudD suppressor of Aspergillus nidulans bimD6 homolog antibody; SudD suppressor of bimD6 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human RIOK3.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.

Gene References into Functions

RIO kinase 3 (RIOK3) positively regulates the activity of the AKT/mTOR pathway in glioma cells. PMID: 29233656
the ectopic expression of RIOK3 or a phosphomimetic MDA5-S828D mutation attenuated MDA5-mediated signaling. PMID: 25865883
These findings demonstrate that RIOK3 is necessary for maintaining actin cytoskeletal organisation required for migration and invasion, biological processes that are necessary for hypoxia-driven metastasis. PMID: 25486436
Functionally, RIOK3 acts as a SUFU-dependent positive regulator of Hedgehog signaling. PMID: 24018050
Authors found that RIOK3 physically interacts with TBK1 and IRF3 and bridges the functions between TBK1 and IRF3 in the activation of type I interferon pathway. PMID: 24807708
RioK3 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA. PMID: 22418843
Like RIOK3, PAK4 promotes pancreas ductal cell motility and invasion in pancreatic cancer PMID: 19050074

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Subcellular Location

Cytoplasm.

Protein Families

Protein kinase superfamily, RIO-type Ser/Thr kinase family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 11451

OMIM: 603579

KEGG: hsa:8780

STRING: 9606.ENSP00000341874

UniGene: Hs.445511

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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