RMND1 Antibody

Datasheet

Code	CSB-PA882123LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: MCF7 whole cell lysate(30µg), HepG2 whole cell lysate(30µg), THP-1 whole cell lysate(30µg) All lanes: RMND1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/20000 dilution Predicted band size: 52,28,24 kDa Observed band size: 52 kDa Exposure time: 120s IHC image of CSB-PA882123LA01HU diluted at 1:50 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody IHC image of CSB-PA882123LA01HU diluted at 1:50 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody IHC image of CSB-PA882123LA01HU diluted at 1:50 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RMND1 Polyclonal antibody

Uniprot No.

Q9NWS8

Target Names

RMND1

Alternative Names

bA351K16 antibody; bA351K16.3 antibody; C6orf96 antibody; chromosome 6 open reading frame 96 antibody; FLJ20627 antibody; MGC117362 antibody; MGC149570 antibody; MGC882602 antibody; required for meiotic nuclear division 1 homolog (S. cerevisiae) antibody; Required for meiotic nuclear division protein 1 homolog antibody; Rmnd1 antibody; RMND1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Required for meiotic nuclear division protein 1 homolog protein (35-160AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RMND1 Antibody (Product code: CSB-PA882123LA01HU) is Non-conjugated. For RMND1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA882123LB01HU	RMND1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA882123LC01HU	RMND1 Antibody, FITC conjugated
Biotin	CSB-PA882123LD01HU	RMND1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.

Gene References into Functions

Hearing impairment and renal failure are associated with RMND1 mutations. PMID: 26395190
Expression of ESR1, RMND1 and CCDC170 associated with variants in separate enhancer elements predisposing breast cancer. [meta-analysis] PMID: 26928228
Results demonstrate that the RMND1 complex is necessary for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome. PMID: 23022098
The RMND1 mutation caused haploinsufficiency that was rescued by overexpression of the wild-type transcript in mutant fibroblasts; this overexpression increased the levels and activities of mitochondrial respiratory-chain proteins. PMID: 23022099

Involvement in disease

Combined oxidative phosphorylation deficiency 11 (COXPD11)

Subcellular Location

Mitochondrion.

Protein Families

RMD1/sif2 family

Database Links

HGNC: 21176

OMIM: 614917

KEGG: hsa:55005

STRING: 9606.ENSP00000356272

UniGene: Hs.486835

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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