RNF2 Antibody

Datasheet
Code CSB-PA859101LA01HU
See More Details
Size US$299
Uniprot No. Q99496
Image
  • Western Blot
    Positive WB detected in: NIH/3T3 whole cell lysate, Jurkat whole cell lysate, HepG2 whole cell lysate
    All lanes: RNF2 antibody at 4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 38, 30 kDa
    Observed band size: 38 kDa

Immunogen Recombinant Human E3 ubiquitin-protein ligase RING2 protein (158-290AA)
Raised in Rabbit
Species Reactivity Human, Mouse
Tested Applications ELISA, WB; Recommended dilution: WB:1:500-1:5000
Relevance E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2), RNF2, BAP1 DING HIPI3 RING1B
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names RNF2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation
Subcellular Location Nucleus, Chromosome
Database Links

HGNC: 10061

OMIM: 608985

KEGG: hsa:6045

STRING: 9606.ENSP00000356480

UniGene: Hs.591490

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