RNGTT Antibody

Code CSB-PA526449ESR2HU
Size US$166
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Image
  • Western blot
    All lanes: RNGTT antibody at 1.42µg/ml + THP-1 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 69, 67, 53, 62 kDa
    Observed band size: 69 kDa

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA526449ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RNGTT Polyclonal antibody
Uniprot No.
Target Names
RNGTT
Alternative Names
CAP1A antibody; GTase antibody; GTP--RNA guanylyltransferase antibody; hCAP antibody; HCAP1 antibody; HcE antibody; HCE1 antibody; MCE1 antibody; MCE1_HUMAN antibody; mRNA 5''-triphosphatase antibody; mRNA capping enzyme antibody; mRNA guanyltransferase antibody; mRNA guanylyltransferase antibody; Polynucleotide 5' trisphosphatase antibody; RNA guanylyltransferase and 5' phosphatase antibody; RNGTT antibody; TPase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human mRNA-capping enzyme protein (1-260AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Gene References into Functions
  1. c-Myc deregulation induces mRNA capping enzyme dependency in tumor cells. PMID: 27756891
  2. These results identify a new domain of CE that is specific to its function in cytoplasmic capping, and a new role for Nck1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex. PMID: 25137142
  3. Our biochemical studies provide the first insight that MZP can inhibit the formation of the RNA cap structure catalyzed by HCE. PMID: 23349942
  4. Data show that human capping enzyme residues 229-567 comprise the minimum enzymatically active human GTase (hGTase) domain and determine the structure by X-ray crystallography. PMID: 21636784
Subcellular Location
Nucleus.
Protein Families
Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family
Tissue Specificity
Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
Database Links

HGNC: 10073

OMIM: 603512

KEGG: hsa:8732

STRING: 9606.ENSP00000358497

UniGene: Hs.567378

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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