RORB Antibody, Biotin conjugated

Code CSB-PA821694LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RORB Polyclonal antibody
Uniprot No.
Target Names
RORB
Alternative Names
bA133M9.1 antibody; NR1F2 antibody; Nuclear receptor ROR-beta antibody; Nuclear receptor RZR beta antibody; Nuclear receptor RZR-beta antibody; Nuclear receptor subfamily 1 group F member 2 antibody; OTTHUMP00000021486 antibody; RAR related orphan receptor B antibody; RAR related orphan receptor beta antibody; Retinoic acid binding receptor beta antibody; Retinoid-related orphan receptor-beta antibody; ROR BETA antibody; Rorb antibody; RORB_HUMAN antibody; RZR BETA antibody; RZRB antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nuclear receptor ROR-beta protein (1-269AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity.; Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4.
Subcellular Location
Nucleus, nucleoplasm.
Protein Families
Nuclear hormone receptor family, NR1 subfamily
Database Links

HGNC: 10259

OMIM: 601972

STRING: 9606.ENSP00000366093

UniGene: Hs.494178

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