RPL10 Antibody

1. The regulation of reactive oxygen species level by mitochondrial RPL10 is one of the major extra-ribosomal functions in pancreatic cancer cells, which could be used as an indicator for the tumorigenesis of pancreatic cancer. PMID: 30172100
2. there are 7 mutations in RPL10 in 344 patients, or a mutation frequency of 2% PMID: 28428269
3. A rare de novo mutation K78E is associated with severe syndromic intellectual disability and epilepsy. PMID: 29066376
4. Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells PMID: 27726420
5. Our results expand the mutational and clinical spectrum of RPL10 identifying a new genetic cause of SED and highlight the emerging role of ribosomal proteins in the pathogenesis of neurodevelopmental disorders. PMID: 26290468
6. report confirms the implication of RPL10 mutations in neurodevelopmental disorders and extends the associated clinical spectrum from autism to syndromic intellectual disability PMID: 25846674
7. A mutation within the conserved N-terminal end of RPL10, a protein in close proximity to the peptidyl transferase active site of the 60S ribosomal subunit, causes severe defects in brain formation and function. PMID: 25316788
8. Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias, with recurrent alterations of Arg98 in RPL10. PMID: 23263491
9. mutation analysis of RPL10 in German patients with autism spectrum disorder PMID: 21567917
10. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism PMID: 16940977
11. QM binds to c-yes at the SH3 domain in tumor cell lines PMID: 12138090
12. Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma PMID: 16331298
13. Xq28 (QM gene) may be involved in ovary failure. PMID: 17566674
14. A hexagonal crystal of L10CD was obtained by the sitting-drop vapour-diffusion method. The L10CD crystal diffracted to 2.5 A resolution and belongs to space group P3(1)21 or P3(2)21. PMID: 18007048
15. Characteristic interactions among Arg90-Trp171-Arg139 guide the C-terminal part outside of the central fold PMID: 18258260
16. Our results suggest that RPL10 has no major effect on the susceptibility to autism spectrum disorders PMID: 19166581

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HGNC: 10298

OMIM: 300847

KEGG: hsa:6134

STRING: 9606.ENSP00000341730

UniGene: Hs.534404