RPRD1B Antibody, FITC conjugated

1. Aberrant overexpression of CREPT contributes to tumorigenesis of colorectal cancer by promoting cell proliferation and accelerating the cell cycle, and confers sensitivity to 5-fluorouracil. PMID: 29398868
2. Ccisplatin-induced peripheral neuropathy(isIPN) is associated with age, modifiable risk factors, and genetically determined expression level of RPRD1B Further study of implicated genes could elucidate the pathophysiologic underpinnings of CisIPN. PMID: 28611204
3. CREPT is closely relevant to the proliferation of NSCLC cells. PMID: 29397041
4. Altogether, our results provided a novel insight into CREPT in regulating gastric cancer progression through apoptosis regulated by ROS/p53 pathways. PMID: 29402413
5. Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC. PMID: 28893536
6. Consistently, samples from oral squamous cell carcinoma (OSCC) patients exhibited a noticeably stronger CREPT expression than noncancerous samples. In contrast, knocking down of CREPT in OSCC cell lines significantly reduced proliferation, colony formation and migration as well as the expression of cyclin D1 and c-Myc, but promoted apoptosis. PMID: 28369091
7. In addition, CREPT overexpression significantly promoted tumor growth in vivo. Mechanism study showed that CREPT may regulate cell proliferation and cell cycle through the regulation on cyclin D3, CDK4 and CDK6. PMID: 27773816
8. a detailed description of proteins associating with K-H/RPRD1B in higher-order protein complexes is required to further elucidate its role in various cellular processes PMID: 26819409
9. CREPT displays unique immunostaining for retroperitoneal leiomyosarcoma tissue and can be used to supplement other currently available markers. PMID: 25400738
10. study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling. PMID: 24982424
11. RPRD1B overexpression promotes tumor growth and accelerates cell cycle progression. PMID: 24452636
12. This study reports that K-H functions in RNAPII regulation, and aids in stabilizing interactions between transcription termination factors, localizing Xrn2 to the 3'-end of genes and ultimately suppressing R-loop formation. PMID: 24589584
13. CREPT increases cyclin D1 transcription during tumorigenesis. PMID: 22264791

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HGNC: 16209

OMIM: 614694

KEGG: hsa:58490

STRING: 9606.ENSP00000362532

UniGene: Hs.278839