RPS19BP1 Antibody

Code CSB-PA070243
Size US$100
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Product Details

Uniprot No.
Target Names
RPS19BP1
Alternative Names
40S ribosomal protein S19 binding protein 1 antibody; 40S ribosomal protein S19-binding protein 1 antibody; Active regulator of SIRT1 antibody; AROS antibody; AROS_HUMAN antibody; Homolog of mouse S19 binding protein antibody; Ribosomal protein S19 binding protein 1 antibody; RPS19 binding protein 1 antibody; RPS19-binding protein 1 antibody; RPS19BP1 antibody; S19BP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Ribosomal Protein S19BP.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.
Gene References into Functions
  1. AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma. PMID: 26339164
  2. In vitro SIRT1 activity assays disclose AROS as an inhibitor of SIRT1. PMID: 24681097
  3. study demonstrated a cancer-specific role for AROS in the regulation of survival in a panel of human cell lines; data suggest that AROS, as well as SIRT1, promotes survival in cancer cells while being redundant for viability in non-cancer cells PMID: 24258275
  4. This study analyses Sirt1 modulation by several putative Sirt1 regulators, showing that the regulator protein AROS has an unusual conformation and that the Sirt1 catalytic domain is sufficient for modulation by resveratrol. PMID: 23548308
  5. we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter. PMID: 23349863
  6. Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation. PMID: 17964266

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Subcellular Location
Nucleus, nucleolus.
Protein Families
AROS family
Tissue Specificity
Widely expressed (at protein level).
Database Links

HGNC: 28749

OMIM: 610225

KEGG: hsa:91582

STRING: 9606.ENSP00000333948

UniGene: Hs.526933

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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