RRBP1 Antibody

1. High RRBP1 expression facilitates colorectal cancer progression and predicts an unfavourable post-operative prognosis. PMID: 26196185
2. Data indicate that p180 is required for the efficient targeting of placental alkaline phosphatase (ALPP) mRNA to the endoplasmic reticulum (ER). PMID: 24019514
3. RRBP1 could alleviate ER stress and help cancer cell survive PMID: 23318453
4. p180 is concentrated in ER sheets by interacting with polysomes and may play a role in ER morphology. PMID: 21111237
5. p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. PMID: 22679391
6. A novel function of p180-abundant endoplasmic reticulum on the trans-Golgi network expansion, both of which are highly developed in various professional secretory cells. PMID: 19932094
7. p180 plays crucial roles in enhancing collagen biosynthesis at the entry site of the secretory compartments by a novel mechanism that mainly involves facilitating ribosome association on the ER. PMID: 20647306
8. Results identify the ribosome receptor, p180, as a binding partner of the kinesin heavy chain isoform KIF5B. PMID: 15184079
9. These data suggest that p180 mediates interactions between the endoplasmic reticulum and microtubules mainly through the novel microtubule-binding and -bundling domain MTB-1. PMID: 17634287
10. over-expression of p180R failed to increase secretory pathway proteins calnexin, SEC61beta, and calreticulin, or ribosome biogenesis PMID: 18083570
11. results obtained demonstrate that p180 is both necessary & sufficient to induce a secretory phenotype in mammalian cells; findings support a central role for p180 in the terminal differentiation of secretory cells & tissues PMID: 19037105
12. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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HGNC: 10448

OMIM: 601418

KEGG: hsa:6238

STRING: 9606.ENSP00000354045

UniGene: Hs.472213