RREB1 Antibody

1. Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant PMID: 29099273
2. RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. PMID: 28341660
3. RREB1 and CCND1 gains are common in nail apparatus melanoma PMID: 27185405
4. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
5. RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. PMID: 25027322
6. The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. PMID: 25050557
7. RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
8. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control PMID: 24418439
9. Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. PMID: 24348900
10. RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. PMID: 22751122
11. These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells PMID: 22427155
12. Data indicate the upregulation of RREB1, PDE6B, and CD209 suggests that these proteins might play important roles in the differentiation of primitive gut tube cells from embryonic stem cells (hESCs) and in primitive gut tube development into pancreas. PMID: 21792086
13. Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. PMID: 21613827
14. RREB1 transcription factor splice variants are associated with urologic cancer. PMID: 21703425
15. KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling PMID: 21159816
16. Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
17. The p16 promoter can be downregulated by transfected human RREB, in a Ras- or Mek-dependent manner, and that the BALB/c promoter is more sensitive than DBA/2 to regulation by RREB, a ras-responsive transcriptional element with zinc-finger binding motifs. PMID: 12700664
18. Finb functions as a sequence-specific transcriptional repressor of the hANG gene PMID: 15067362
19. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape PMID: 18394891
20. Findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage. PMID: 19558368
21. This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms. PMID: 19890057

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HGNC: 10449

OMIM: 602209

KEGG: hsa:6239

UniGene: Hs.298248