RTN4RL2 Antibody, FITC conjugated

Code CSB-PA774805NC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RTN4RL2 Polyclonal antibody
Uniprot No.
Target Names
RTN4RL2
Alternative Names
RTN4RL2 antibody; NGRH1 antibody; NGRL3 antibody; Reticulon-4 receptor-like 2 antibody; Nogo receptor-like 3 antibody; Nogo-66 receptor homolog 1 antibody; Nogo-66 receptor-related protein 2 antibody; NgR2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Reticulon-4 receptor-like 2 protein (355-372AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
Gene References into Functions
  1. Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] PMID: 24956133
  2. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
  3. predominantly expressed in the neurons of the embryonic and adult nervous systems PMID: 14664809
  4. The release of N-terminal fragment-NgRH1 was blocked by a hydroxamate-based zinc metalloproteinase inhibitor and tissue inhibitor of metalloproteinases-2 and -3 PMID: 15629437
  5. Nogo-66 receptor homolog 1 signaling regulates activity-dependent synaptic strength and neuronal plasticity. PMID: 18337405

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Perikaryon. Cell projection, axon.
Protein Families
Nogo receptor family
Tissue Specificity
Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
Database Links

HGNC: 23053

OMIM: 610462

KEGG: hsa:349667

STRING: 9606.ENSP00000335397

UniGene: Hs.502618

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