S1PR4 Antibody

Code CSB-PA002251
Size US$167
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  • Western Blot analysis of HepG2 cells using EDG-6 Polyclonal Antibody
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Product Details

Uniprot No. O95977
Target Names S1PR4
Alternative Names EDG6 antibody; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 6 antibody; Endothelial differentiation G protein coupled receptor 6 antibody; Endothelial differentiation G-protein coupled receptor 6 antibody; Endothelial differentiation gene 6 antibody; LPC1 antibody; Lysophospholipid receptor C1 antibody; MGC129298 antibody; Putative G protein coupled receptor antibody; S1P receptor 4 antibody; S1P receptor Edg-6 antibody; S1P receptor Edg6 antibody; S1P4 antibody; S1PR4 antibody; S1PR4_HUMAN antibody; SLP4 antibody; Sphingosine 1 phosphate receptor 4 antibody; Sphingosine 1 phosphate receptor Edg6 antibody; Sphingosine 1-phosphate receptor 4 antibody; Sphingosine 1-phosphate receptor Edg-6 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of Human EDG-6.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:5000
Protocols Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
Gene References into Functions
  1. High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis. PMID: 28206609
  2. S1PR4 missense mutation is associated with variant blood cell traits. PMID: 27399967
  3. Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs. PMID: 28148497
  4. Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/9 ligands to allow high IFN-alpha production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha secretion. PMID: 26783340
  5. S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4. PMID: 24486401
  6. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists PMID: 22119461
  7. findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression. PMID: 22460268
  8. Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells. PMID: 20837468
  9. Data report that sphingosine 1-phosphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells PMID: 20686109
  10. Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species PMID: 15298705
  11. FOXO1 controls the expression of L-selectin and EDG1 and EDG6, receptors that regulate lymphocyte trafficking PMID: 18713968

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone
Database Links

HGNC: 3170

OMIM: 603751

KEGG: hsa:8698

STRING: 9606.ENSP00000246115

UniGene: Hs.662006

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