SCGN Antibody

1. the overexpression of SCGN in SW480 human colorectal cancer cells promoted cell apoptosis and inhibited cell migration and invasion. PMID: 29499408
2. Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein secretagogin, which dissociates from tomosyn1 in response to Ca(2+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2+) influx. PMID: 28325894
3. secretagogin is a potential biomarker, reflecting stress and islet cell dysfunction in T2D patients PMID: 29702679
4. Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration. PMID: 28223495
5. The low SCGN plasma levels in children with ASD probably indicate that SCGN might be implicated in the pathogenesis of autism. However, these data should be treated with caution until further investigations are performed using larger sample sizes to determine whether the decrease in plasma SCGN levels is a mere consequence of autism or it plays a pathogenic role in the disease. PMID: 28492151
6. Therefore, and considering the desensitization of TRPV1s in diabetic pancreata, a TRPV1-to-secretagogin regulatory axis seems critical to maintain the structural integrity and signal competence of beta-cells. PMID: 28637794
7. These results suggest SCGN is involved in the chemoresistance of small cell lung cancer under the regulation of miR-494 PMID: 25226615
8. Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn. PMID: 23102406
9. While secretagogin mRNA was detected in both peripheral mononuclear cells and erythrocytes using reverse-transcription polymerase chain reaction, SCGN protein was only detected in erythrocytes. PMID: 22921511
10. Data show that the density of secretagogin-positive neurons selectively decreases in the olfactory tract in Alzheimer's disease. PMID: 22474393
11. Levels of secretagogin correlate with mortality and are useful as predictors of outcome in children with traumatic brain injury. PMID: 21976236
12. Ddetection of novel calcium-binding protein secretagogin within subgroup of clear-cell renal cell carcinomas. Increased metastasis rates within secretagogin-positive subgroup of clear-cell renal cell carcinomas. PMID: 21288557
13. Results emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries. PMID: 20529129
14. Secretagogin might play a role in human non-functional pituitary adenomas. This novel finding may provide clues to clarify the basic molecular mechanisms of pituitary adenoma formation, and to identify new tumor-related markers. PMID: 15237930
15. two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin PMID: 15766553
16. We identified and characterized promoter activity of a human 1498 bp secretagogin sequence upstream the transcription start site. PMID: 17083620

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HGNC: 16941

OMIM: 609202

KEGG: hsa:10590

STRING: 9606.ENSP00000367197

UniGene: Hs.116428