SCN11A Antibody

Code CSB-PA883417LA01HU
Size US$166
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  • IHC image of CSB-PA883417LA01HU diluted at 1:500 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA883417LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA883417LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SCN11A Polyclonal antibody
Uniprot No.
Target Names
SCN11A
Alternative Names
hNaN antibody; NaN antibody; NAV1.9 antibody; Peripheral nerve sodium channel 5 antibody; PN 5 antibody; PN5 antibody; SCN 11A antibody; SCN 12A antibody; Scn11a antibody; SCN12A antibody; SCNBA_HUMAN antibody; Sensory neuron sodium channel 2 antibody; SNS 2 antibody; SNS2 antibody; Sodium channel protein type 11 subunit alpha antibody; Sodium channel protein type XI subunit alpha antibody; Sodium channel voltage gated type XI alpha antibody; Sodium channel voltage gated type XI alpha polypeptide antibody; Sodium channel voltage gated type XI alpha subunit antibody; Sodium channel voltage gated type XII alpha polypeptide antibody; Voltage gated sodium channel Nav1.9 antibody; Voltage gated sodium channel subunit alpha Nav1.9 antibody; Voltage-gated sodium channel subunit alpha Nav1.9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sodium channel protein type 11 subunit alpha protein (403-551AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SCN11A Antibody (Product code: CSB-PA883417LA01HU) is Non-conjugated. For SCN11A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA883417LB01HU SCN11A Antibody, HRP conjugated ELISA
FITC CSB-PA883417LC01HU SCN11A Antibody, FITC conjugated
Biotin CSB-PA883417LD01HU SCN11A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Gene References into Functions
  1. We identified a missense mutation of p.Arg225Cys in SCN11A in a four-generation Chinese family with early-onset familial episodic pain and adult onset familial essential tremor syndrome. PMID: 28298626
  2. SCN11A single-nucleotide polymorphisms affect Postoperative pain sensitivity in Chinese Han women after Gynecological surgery. The SNP rs33985936 and rs13080116 may serve as novel predictors for Postoperative pain. PMID: 28953656
  3. a U-shaped relationship between the resting potential and the neuronal action potential threshold explains why NaV1.9 mutations that evoke small degrees of membrane depolarization cause hyperexcitability and familial episodic pain disorder or painful neuropathy, while mutations evoking larger membrane depolarizations cause hypoexcitability and insensitivity to pain. PMID: 28530638
  4. Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain syndromes. PMID: 27224030
  5. Results show the expression of Nav1.9 channels within the human colon for the first time. Furthermore, Nav1.9 channel expression is decreased in Hirschsprung's disease versus normal controls. PMID: 27297039
  6. autosomal dominant Congenital insensitivity to pain reflects the second gain-of-function mutation of SCN11A. PMID: 26746779
  7. A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain. PMID: 26645915
  8. A G699R substitution in the Nav1.9 domain II S4-S5 linker renders dorsal root ganglion neurons hyperexcitable, via depolarized resting membrane potential, reduced current threshold and increased evoked firing in small-fiber neuropathy. PMID: 25791876
  9. missense mutations of Nav1.9 in individuals with painful peripheral neuropathy PMID: 24776970
  10. The results demonstrate that Nav1.8 and Nav1.9 are present in human lingual nerve neuromas, with significant correlations between the level of expression of Nav1.8 and symptoms of pain. PMID: 24144460
  11. we identified a specific de novo missense mutation in SCN11A in individuals with the congenital inability to experience pain who suffer from recurrent tissue damage and severe mutilations. PMID: 24036948
  12. Gain-of-function mutations in SCN11A can be causative of an autosomal-dominant episodic pain disorder. PMID: 24207120
  13. Results provide evidence that Nav1.9 plays a crucial role in the generation of heat and mechanical pain hypersensitivity, both in subacute and chronic inflammatory pain models. PMID: 21857998
  14. we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation PMID: 12384689

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Involvement in disease
Neuropathy, hereditary sensory and autonomic, 7 (HSAN7); Episodic pain syndrome, familial, 3 (FEPS3)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Sodium channel (TC 1.A.1.10) family, Nav1.9/SCN11A subfamily
Tissue Specificity
Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
Database Links

HGNC: 10583

OMIM: 604385

KEGG: hsa:11280

STRING: 9606.ENSP00000307599

UniGene: Hs.591657

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