SCN11A Antibody, Biotin conjugated

Datasheet

Code CSB-PA883417LD01HU
Size US$299
Uniprot No. Q9UI33
Immunogen Recombinant Human Sodium channel protein type 11 subunit alpha protein (403-551AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN), SCN11A, SCN12A SNS2
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Neuroscience
Target Names SCN11A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Involvement in disease Neuropathy, hereditary sensory and autonomic, 7 (HSAN7); Episodic pain syndrome, familial, 3 (FEPS3)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Sodium channel (TC 1.A.1.10) family, Nav1.9/SCN11A subfamily
Tissue Specificity Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
Database Links

HGNC: 10583

OMIM: 604385

KEGG: hsa:11280

STRING: 9606.ENSP00000307599

UniGene: Hs.591657

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