SCYL2 Antibody

Code CSB-PA020874GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
AU015688 antibody; AW536445 antibody; BC030932 antibody; Coated vesicle-associated kinase of 104 kDa antibody; CVAK104 antibody; D10Ertd802e antibody; FLJ10074 antibody; KIAA1360 antibody; RGD1305665 antibody; SCY1 like 2 (S. cerevisiae) antibody; SCY1 like protein 2 antibody; SCY1-like protein 2 antibody; SCYL2 antibody; SCYL2_HUMAN antibody
Raised in
Species Reactivity
Human SCYL2
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development.
Gene References into Functions
  1. results suggest that SCYL2 serves as a regulatory factor for Vpu, reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction. PMID: 23047923
  2. CVAK104 binds ATP and functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin subunit of AP2. PMID: 15809293
  3. Together, our data suggest a function for CVAK104 in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. PMID: 16914521
  4. CVAK104 is an evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development PMID: 17587408
  5. Studies identify CVAK104 as a novel binding partner of Dishevelled (Dvl) and that CVAK104 also interacts with Fzd5. PMID: 19643732

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Subcellular Location
Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane.
Protein Families
Protein kinase superfamily
Database Links

HGNC: 19286

OMIM: 616365

KEGG: hsa:55681

STRING: 9606.ENSP00000354061

UniGene: Hs.506481

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