SDPR Antibody

1. SDPR variants were not associated with major depressive disorder. PMID: 27721187
2. Overall, these data suggest that Cavin-2 represents a useful marker for discriminating the degree of differentiation in LPS tumors. PMID: 28865960
3. Data found that CVN2 expression was signi fi cantly down-regulated in oral squamous cell carcinoma (OSCC) in vitro and in vivo and that CVN2 overexpression led to decreased proliferative activities through the CVN2/caveolin-1/ERK path- way. Furthermore, high tumoral progression occurred in CVN2-negative patients with OSCC. PMID: 26086332
4. Hepatocellular carcinoma patients with lower cavin-2 expression have a relatively poor prognosis. PMID: 27513662
5. identification of a novel metastasis suppressor gene, serum deprivation response (SDPR), localized to 2q32-33, a region reported to be associated with significant loss of heterozygosity in breast cancer, is reported. PMID: 26739564
6. Cavin-1 and cavin-2 are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1. PMID: 26086560
7. Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 and cavin3. PMID: 24473072
8. Three genes (LY96, IL8 DPR) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8). PMID: 25124890
9. The cavin family protein Polymerase 1 and transcript release factor, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue. PMID: 21913217
10. Study conclude that SDPR is a membrane-curvature-inducing component of caveolae, and that STB-induced membrane tubulation is facilitated by caveolae. PMID: 19525939

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HGNC: 10690

OMIM: 606728

KEGG: hsa:8436

STRING: 9606.ENSP00000305675

UniGene: Hs.26530