SEMA4B Antibody, Biotin conjugated

Code CSB-PA868280LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SEMA4B Polyclonal antibody
Uniprot No.
Target Names
SEMA4B
Alternative Names
SEMA4B antibody; KIAA1745 antibody; SEMAC antibody; UNQ749/PRO1480 antibody; Semaphorin-4B antibody; Semaphorin-C antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Semaphorin-4B protein (163-253AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Gene References into Functions
  1. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. PMID: 25746385
  2. Decrease in SEMA4b levels are associated with metastasis of non-small cell lung cancer. PMID: 25095981
  3. showed that HIF-1alpha recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression PMID: 24474252
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Semaphorin family
Database Links

HGNC: 10730

KEGG: hsa:10509

STRING: 9606.ENSP00000332204

UniGene: Hs.474935

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